An Historical Review of Steps and Missteps in the Discovery of
Por um escritor misterioso
Last updated 26 setembro 2024
The epidemic of obesity cries out for strategies to prevent it, and for treatment when prevention fails. Yet despite the obvious need, the path to developing anti-obesity medications is strewn with failures. This review examines some historical developments in the management of obesity prior to the 20th century followed by more recent efforts to find a “cure.” Since obesity has been a human disease since paleolithic times, discussion of treatment prior to the scientific revolution in about 1500 CE will include comments on treatment of obesity in Grecian Medicine and the Treatment of Sancho “The Fat” King of Leon in 10th century northern Spain. We will then trace treatment trends through time, ending in the early 21st century. In the first half of the 20th century there were 3 main themes associated with drug treatment of obesity: use of thyroid hormones, the interlude with dinitrophenol as drug regulation was beginning to expand, and the introduction of amphetamines and Rainbow Pills. In the second half of the 20th century many new treatment approaches were explored as the scientific basis for understanding regulation of food intake expanded, particularly after the discovery of leptin in 1994. The fact that amphetamine could be addictive led to the search for compounds that acted in the central nervous system with retained the anorectic properties but were not addictive. Both anti-depressant and anticonvulsive drugs were evaluated with disappointing results. The idea of enhancing energy expenditure with thermogenic drugs was pursued but led to a dead end. Peptides, metabolic drugs and drugs that act on the gastrointestinal track are currently under exploration. This chapter makes an effort to answer the question of why it has been so difficult to develop effective medications for the management of obesity. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text, WWW.ENDOTEXT.ORG.
How To Set Up Accurate Document Review In Five Steps
30 Job Search Mistakes to Avoid (and What to Do Instead)
What are flash sales? A Step-By-Step Guide With Examples
7 common options trading mistakes - Fidelity
16 First-time Homebuyer Mistakes to Avoid
Database Design Bad Practices
Pompeii Guide: 10 Things to Know Before Visiting the Ancient Roman
Artificial Intelligence Is Rushing Into Patient Care - And Could
Academic Paragraph Structure Step-by-Step Guide & Examples
Recomendado para você
-
Bronstein (Leblon) • Telefone e Endereço - Sou Leblon26 setembro 2024
-
Gmail - Bronstein Mega Méier26 setembro 2024
-
PDF) The Latin East in the 13th Century - Program.pdf26 setembro 2024
-
Checkmate Grandmaster! - Winning In The Opening - Chess Lessons26 setembro 2024
-
Bastian RIECK, Principal Investigator, Ph.D.26 setembro 2024
-
Formation of 1-Butanol from CO2 without *CO Dimerization on a26 setembro 2024
-
Sabres Can't Complete Comeback News, Sports, Jobs - Post Journal26 setembro 2024
-
Gmail - Confirmação de Agendamento - Bronstein Medicina Diagnóstica26 setembro 2024
-
Apartamento na Rua Dias da Cruz, 335, Méier em Rio de Janeiro, por26 setembro 2024
-
TOBIAS MEIER Balanced complexity with fine art - Photography26 setembro 2024
você pode gostar
-
Play MineCraft.io Free Online Games. KidzSearch.com26 setembro 2024
-
Trader Games - EVIL DEAD THE GAME PS5 FR NEW on Playstation 526 setembro 2024
-
Pounoia memes. Best Collection of funny Pounoia pictures on iFunny Brazil26 setembro 2024
-
Drainage Basin Definition, System & Characteristics - Video26 setembro 2024
-
Otome Game no Hametsu Flag shika nai Akuyaku Reijou ni Tensei shite shimatta Web Comic26 setembro 2024
-
Gachapon - August 2022] FUUTO TANTEI CAPSULE RUBBER MASCOT - 40pcs - Bandai Gachapon26 setembro 2024
-
T-shirt.roblox.Video games.popular Essential T-Shirt for Sale by haroun70026 setembro 2024
-
A Plague Tale: Requiem will launch in 2022, joining Xbox Game Pass26 setembro 2024
-
easy lego roblox avatar tutorial #lego #legos #legoroblox #roblox #rob26 setembro 2024
-
Buy Rise of the Tomb Raider26 setembro 2024