Cancers, Free Full-Text

Por um escritor misterioso
Last updated 23 dezembro 2024
Cancers, Free Full-Text
We recently observed that Compound C (CompC), a reversible inhibitor of AMP-activated protein kinase, reduced the cell viability of B16-F1 melanoma cells. To establish its molecular mechanism(s) of action, the cell cycle was examined by flow cytometry and the expression of cell cycle regulatory proteins and angiogenesis-related proteins were examined by western blot analysis. In addition, its effect on tumor growth was investigated using C57BL/6 syngeneic mice bearing B16-F1 xenografts. We found that CompC induced G2/M cell cycle arrest, which was associated with reduced levels of cell cycle regulatory proteins, such as phosphorylated pRB, cyclin-dependent protein kinases (Cdks), cyclins, and phosphorylated P-Ser10-histone H3, and increased levels of Cdk inhibitors, such as p21 and p53. We also found that CompC inhibits proliferation, migration, and tube formation of human umbilical vascular endothelial cells via the inhibition of vascular endothelial growth factor receptor-induced signaling pathways. As expected, CompC significantly reduced the tumor size of B16-F1 xenografts in the syngeneic mouse model. Inhibition of tumor growth may be attributed to reduced cell proliferation via cell cycle inhibition and in part to decreased angiogenesis in CompC-treated mice. These findings suggest the potential use of CompC against melanoma development and progression.
Cancers, Free Full-Text
Event-free Survival with Pembrolizumab in Early Triple-Negative
Cancers, Free Full-Text
Home - Free ME from Lung Cancer
Cancers, Free Full-Text
Cancers, Free Full-Text
Cancers, Free Full-Text
A Randomized Trial of Letrozole in Postmenopausal Women after Five
Cancers, Free Full-Text
Gist Ot Typing Tool Software Free - Colaboratory
Cancers, Free Full-Text
Hypercalcemia and treated breast cancers: The diagnostic dilemma
Cancers, Free Full-Text
Emerging cancer trends among young adults in the USA: analysis of
Cancers, Free Full-Text
Pathology Outlines - Carcinoma-general
Cancers, Free Full-Text
I Am Cancer Free! - Cancer Free Gift - Pin
Cancers, Free Full-Text
6 versus 12 months of adjuvant trastuzumab for HER2-positive early
Cancers, Free Full-Text
Cell-free nucleic acids as biomarkers in cancer patients
Cancers, Free Full-Text
Cancers, Free Full-Text
Cancers, Free Full-Text
Dr 2.4.2 Dota 1 Free Download - Colaboratory
Cancers, Free Full-Text
Journal of Cancer Research and Clinical Oncology
Cancers, Free Full-Text
Weekly Paclitaxel in the Adjuvant Treatment of Breast Cancer

© 2014-2024 immanuelipc.com. All rights reserved.