Homobivalent Dopamine D2 Receptor Ligands Modulate the Dynamic Equilibrium of D2 Monomers and Homo- and Heterodimers

Schematic model, showing possible downstream signaling by (transient)

The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics

Biphasic competition-binding curves indicate a bivalent binding mode.

Clozapine-based homobivalent ligands 1a–1f, 2a–2 g and 3a–3 g [22]

Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches

Cross-linking of D2R to a homodimer by copper phenanthroline . A

A structure-guided approach for the design of bivalent ligands. On the

PDF) The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer

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Homobivalent Dopamine D2 Receptor Ligands Modulate the Dynamic Equilibrium of D2 Monomers and Homo- and Heterodimers