Diseases, Free Full-Text

(1) Introduction: Traumatic brain injury (TBI) is a leading cause of injury and mortality worldwide, carrying an estimated cost of $38 billion in the United States alone. Neutrophil to lymphocyte ratio (NLR) has been investigated as a standardized biomarker that can be used to predict outcomes of TBI. The aim of this review was to determine the prognostic utility of NLR among patients admitted for TBI. (2) Methods: A literature search was conducted in PubMed, Scopus, and Web of Science in November 2022 to retrieve articles regarding the use of neutrophil to lymphocyte ratio (NLR) as a prognostic measure in traumatic brain injury (TBI) patients. Inclusion criteria included studies reporting outcomes of TBI patients with associated NLR values. Exclusion criteria were studies reporting only non-primary data, those insufficiently disaggregated to extract NLR data, and non-English or cadaveric studies. The Newcastle-Ottawa Scale was utilized to assess for the presence of bias in included studies. (3) Results: Following the final study selection 19 articles were included for quantitative and qualitative analysis. The average age was 46.25 years. Of the 7750 patients, 73% were male. Average GCS at presentation was 10.51. There was no significant difference in the NLR between surgical vs. non-surgical cohorts (SMD 2.41 95% CI −1.82 to 6.63, p = 0.264). There was no significant difference in the NLR between bleeding vs. non-bleeding cohorts (SMD 4.84 95% CI −0.26 to 9.93, p = 0.0627). There was a significant increase in the NLR between favorable vs. non-favorable cohorts (SMD 1.31 95% CI 0.33 to 2.29, p = 0.0090). (4) Conclusions: Our study found that NLR was only significantly predictive for adverse outcomes in TBI patients and not surgical treatment or intracranial hemorrhage, making it nonetheless an affordable alternative for physicians to assess patient prognosis.

Pinkbook Course Book: Epidemiology of Vaccine Preventable Diseases

A randomized-controlled trial of ischemia-free liver transplantation for end-stage liver disease - ScienceDirect

Frontiers Serum/plasma biomarkers and the progression of cardiometabolic multimorbidity: a systematic review and meta-analysis

RePub, Erasmus University Repository: Modeling human brain diseases using pluripotent stem cells

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 - The Lancet

Climate Change and Vectorborne Diseases

Foot and mouth disease - WOAH - World Organisation for Animal Health

Eradication of Diseases - Our World in Data

Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease

Report: Healthy Fossil Fuel Free World Means Re-Imagining New Clean Energy Future - The Global Climate and Health Alliance

COVID-19 Update: Bone Marrow Failure and Infectious Diseases