EB2 pS222 antibody

EB2 S222 site is a target for phosphorylation by the CDKL5 protein kinase; loss-of-function mutations in the human CDKL5 gene are associated with CDKL5 Deficiency Disorder, a neurodevelopmental disorder with intractable epilepsy (Baltussen, Negraes, et al

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics. - Abstract - Europe PMC

Litterature

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

PDF) Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics. - Abstract - Europe PMC