Vaccines, Free Full-Text
Por um escritor misterioso
Last updated 20 setembro 2024
The ideal vaccine against viral infections should elicit antibody responses that protect against divergent strains. Designing broadly protective vaccines against SARS-CoV-2 and other divergent viruses requires insight into the specific targets of cross-protective antibodies on the viral surface protein(s). However, unlike therapeutic monoclonal antibodies, the B-cell epitopes of vaccine-induced polyclonal antibody responses remain poorly defined. Here we show that, through the combination of neutralizing antibody functional responses with B-cell epitope mapping, it is possible to identify unique antibody targets associated with neutralization breadth. The polyclonal antibody profiles of SARS-CoV-2 index-strain-vaccinated rabbits that demonstrated a low, intermediate, or high neutralization efficiency of different SARS-CoV-2 variants of concern (VOCs) were distinctly different. Animals with an intermediate and high cross-neutralization of VOCs targeted fewer antigenic sites on the spike protein and targeted one particular epitope, subdomain 1 (SD1), situated outside the receptor binding domain (RBD). Our results indicate that a targeted functional antibody response and an additional focus on non-RBD epitopes could be effective for broad protection against different SARS-CoV-2 variants. We anticipate that the approach taken in this study can be applied to other viral vaccines for identifying future epitopes that confer cross-neutralizing antibody responses, and that our findings will inform a rational vaccine design for SARS-CoV-2.
World leaders unite in call for a people's vaccine against COVID
News Flash • Get an Updated 2023-2024 COVID-19 Vaccine at No
Duration of effectiveness of vaccines against SARS-CoV-2 infection
Insurance Coverage of Updated COVID-19 Vaccines: A Cheat Sheet
2021 Free Flu Shots – Lexington-Fayette County Health Department
12+ Vaccine Infographics to Increase Vaccination Rates
COVID-19 Vaccination Clinical and Professional Resources
COVID-19 Vaccine COVID-19 Vaccine
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis
FREE Vaccine Clinic - Santa Rita School
Covid-19 Vaccinations: County and State Tracker - The New York Times
Vaccines, Free Full-Text
COVID-19 vaccine hesitancy in a representative working-age
Recomendado para você
-
Erroll Garner Plays for Dancing Record20 setembro 2024
-
Motor caixa evaporadora com turbina RC.530.057 em Promoção na20 setembro 2024
-
1851 map. Ancient AFRICA ANTIQUA Lea & Blanchard: Phil. 7x9.5 VG-FINE20 setembro 2024
-
Masilamani V G20 setembro 2024
-
Luiz Arruda: 201520 setembro 2024
-
Fabian 45 Vinyl Record Got the Feeling / Come on and Get20 setembro 2024
-
V G Security Services in Market Yard,Sangli - Best Security20 setembro 2024
-
Viruses, Free Full-Text20 setembro 2024
-
Frontiers Breeding for Climate Change Resilience: A Case Study20 setembro 2024
-
Structure−Activity Relationship of Purine Ribonucleosides for20 setembro 2024
você pode gostar
-
Alteraciones de parámetros de laboratorio en pacientes con SARS-CoV-220 setembro 2024
-
Cyberpunk Edgerunners - Lucy neon light Canvas Print for Sale by20 setembro 2024
-
Conception II: Children of the Seven Stars Video game God Eater 220 setembro 2024
-
Dante 💥 It's Showtime! on X: Devil May Cry 2 concept art of Dante and his Devil Triggers / X20 setembro 2024
-
HBO's The Last Of Us Season 2 Abby Actress Possibly Leaked20 setembro 2024
-
Demon Slayer: Kimetsu no Yaiba Episode 1 Recap. – xxanimexxgirlxx20 setembro 2024
-
I did not want a plot told of Light's failure”: Death Note Creator Despised the Idea of Light Yagami to Die a Villain, Did Everything in his Power to Redeem Him20 setembro 2024
-
Legends Never Die - Apple Music20 setembro 2024
-
Monopoly Go Singles Day Tournament Rewards List for November 13-14, 2023 [Update] - GameRevolution20 setembro 2024
-
All animatronics w/ anime character creator w/ actual animatronics20 setembro 2024