GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. - Abstract - Europe PMC

D3-GPC2-PBD is potently cytotoxic to GPC2-expressing SCLCs (A)

A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors - ScienceDirect

Membrane Proteome Array (MPA), Antibody Specificity Profiling

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours. - Abstract - Europe PMC

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours. - Abstract - Europe PMC

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting