Cetuximab, irinotecan and fluorouracile in fiRst-line treatment of
Por um escritor misterioso
Last updated 22 setembro 2024
Background Combination of chemotherapies (fluoropirimidines, oxaliplatin and irinotecan) with biologic drugs (bevacizumab, panitumumab, cetuximab) have improved clinical responses and survival of metastatic colorectal cancer (mCRC). However, patients’ selection thorough the identification of predictive factors still represent a challange. Cetuximab (Erbitux®), a chimeric monoclonal antibody binding to the Epidermal Growth Factor Receptor (EGFR), belongs to the Immunoglobulins (Ig) grade 1 subclass able to elicite both in vitro and in vivo the Antibody-Dependent Cell-mediated Cytotoxicity (ADCC). ADCC is the cytotoxic killing of antibody-coated target cells by immunologic effectors. The effector cells express a receptor for the Fc portion of these antibodies (FcγR); genetic polymorphisms of FcγR modify the binding affinity with the Fc of IgG1. Interestingly, the high-affinity FcγRIIIa V/V is associated with increased ADCC in vitro and in vivo. Thus, ADCC could partially account for cetuximab activity. Methods/design CIFRA is a single arm, open-label, phase II study assessing the activity of cetuximab in combination with irinotecan and fluorouracile in FcγRIIIa V/V patients with KRAS, NRAS, BRAF wild type mCRC. The study is designed with a two-stage Simon model based on a hypothetical higher response rate (+ 10%) of FcγRIIIa V/V patients as compared to previous trials (about 60%) assuming ADCC as one of the possible mechanisms of cetuximab action. The test power is 95%, the alpha value of the I-type error is 5%. With these assumptions the sample for passing the first stage is 14 patients with > 6 responses and the final sample is 34 patients with > 18 responses to draw positive conclusions. Secondary objectives include toxicity, responses’ duration, progression-free and overall survival. Furthermore, an associated translational study will assess the patients’ cetuximab-mediated ADCC and characterize the tumor microenvironment. Discussion The CIFRA study will determine whether ADCC contributes to cetuximab activity in mCRC patients selected on an innovative immunological screening. Data from the translational study will support results’ interpretation as well as provide new insights in host-tumor interactions and cetuximab activity. Trial registration The CIFRA trial (version 0.0, June 21, 2018) has been registered into the NIH-US National Library of Medicine, ClinicalTrials.gov database with the identifier number ( NCT03874062 ).
Comparison of Panitumumab Plus Irinotecan and Cetuximab Plus
Frontiers Molecular and genetic targets within metastatic
First-line trifluridine/tipiracil plus bevacizumab for
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first
Cetuximab plus chronomodulated irinotecan, 5-fluorouracil
New Treatment Options for Colorectal Cancer
The addition of bevacizumab in the first-line treatment for
CHEMORADIOTHERAPY FOR COLORECTAL CANCER
Metastatic Colorectal Cancer, mCRC, HCP
Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan
Addition of cetuximab to chemotherapy shortens OS in advanced
New Treatment Options for Colorectal Cancer
Treatment dilemmas of cetuximab combined with chemotherapy for
Recomendado para você
-
Super Partituras - Toxic v.4 (Cathy Dennnis, Christian Karlsson22 setembro 2024
-
CREEP - Beginner Uke Chord Chart PDF, PDF22 setembro 2024
-
Cifra Club - Tones and I - Dance Monkey, PDF22 setembro 2024
-
Toxic - Britney Spears Ukulele Tutorial 💕✨ #ukulele22 setembro 2024
-
Toxic - BoyWithUke Cifra para Ukulele [Uke Cifras]22 setembro 2024
-
Super Partituras - Hold It Against Me (Britney Spears), com cifra22 setembro 2024
-
Super Partituras - The Hook Up (Britney Spears, Christopher22 setembro 2024
-
Toxic - Britney Spears - Cifra Club22 setembro 2024
-
Health risk assessment of potentially toxic elements in the dry22 setembro 2024
-
Toxic - Britney Spears Cifra para Ukulele [Uke Cifras]22 setembro 2024
você pode gostar
-
COMO DESENHAR A GALINHA PINTADINHA /// HOW TO DRAW PAINTED CHICKEN22 setembro 2024
-
Koi wa Sekai Seifuku no Ato de Icon by NocturneXI on DeviantArt22 setembro 2024
-
Naruto: Hokage connection guide – animejnr22 setembro 2024
-
The Eminence in Shadow [2022] Review in Hindi, Anime22 setembro 2024
-
Tribute to Let me solo her 🏺🙏🏻🏺 : r/Eldenring22 setembro 2024
-
Espada Dracule Mihawk One Piece Cosplay Gigante Em Aço22 setembro 2024
-
Kingdom Hearts (series), Disney Wiki22 setembro 2024
-
I'm the King of the Castle (by Susan Hill) by matt ellis on Prezi Next22 setembro 2024
-
Mais de 1,90 m. Vem saber quem são os grandalhões de Hollywood - OFuxico22 setembro 2024
-
desenhos, #passoapasso, #comofazer, #manga, #anime, #olhos, #designs Para Melhorar O Seu Desenho.22 setembro 2024