Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

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B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells - ScienceDirect

X chromosome Inactivation

Landscape of X chromosome inactivation across human tissues

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Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing, Epigenetics & Chromatin

The X chromosome in immune functions: when a chromosome makes the difference

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