Marvel's Spider-Man's Doctor Octopus Should Lead to a Monstrous

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How is Dr. Octopus able to withstand punches to the face from Spider-Man if he doesn't actually have genetic superpowers that make him stronger or more resistant to that type of damage?

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LEGO Marvel Spider-Man: Spider-Man's Monster Truck vs. Mysterio 76174; Cool Construction Toy (439 Pieces)