Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

Promoting the clearance of neurotoxic proteins in

PDF) Overlapping Neuroimmune Mechanisms and Therapeutic Targets in

Silva Katusic Hecimovic - Senior Scientist - Ruđer Bošković

Marko Košiček - Science communication coordinator - Ruđer Bošković

Silva Katusic Hecimovic - Senior Scientist - Ruđer Bošković Institute

Molecular mechanism(s) of cholesterol-effect on APP and BACE1

Marko KOSICEK, PhD, Ruđer Bošković Institute, Zagreb

Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C

Niemann-Pick disease type C

PDF) Impaired Retromer Function in Niemann-Pick Type C Disease Is

IJMS, Free Full-Text

PDF) Involvement of the Choroid Plexus in the Pathogenesis of